Cellular responses to replication stress: Implications in cancer biology and therapy

DNA Repair (Amst). 2017 Jan:49:9-20. doi: 10.1016/j.dnarep.2016.11.002. Epub 2016 Nov 22.

Abstract

DNA replication is essential for cell proliferation. Any obstacles during replication cause replication stress, which may lead to genomic instability and cancer formation. In this review, we summarize the physiological DNA replication process and the normal cellular response to replication stress. We also outline specialized therapies in clinical trials based on current knowledge and future perspectives in the field.

Keywords: Cancer; Clinical trials; DNA replication; Genomic instability; Replication stress.

Publication types

  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / therapeutic use
  • Clinical Trials as Topic
  • DNA Damage*
  • DNA Repair*
  • DNA Replication*
  • Genomic Instability
  • Humans
  • Neoplasms / drug therapy
  • Neoplasms / genetics*
  • Neoplasms / metabolism

Substances

  • Antineoplastic Agents