Rh-Catalyzed Chemo- and Enantioselective Hydrogenation of Allylic Hydrazones

Abstract

A highly efficient P-stereogenic diphosphine-rhodium complex was applied to the chemo- and enantioselective hydrogenation of allylic hydrazones for the synthesis of chiral allylic hydrazines in 89-96 % yields and with 82-99 % ee values. This methodology was successfully applied to the preparation of versatile chiral allylic amine derivatives.

Keywords: P-stereogenic diphosphine; allylic amines; allylic hydrazines; asymmetric synthesis; hydrazones.