Reaction of Lymphoid Organs to Injection of Iron-Carbon Nanoparticles

Bull Exp Biol Med. 2016 Dec;162(2):252-254. doi: 10.1007/s10517-016-3588-7. Epub 2016 Dec 1.

Abstract

The distribution of iron-carbon nanoparticles in FeC-DSPE-PEG-2000 modification (micellar particles with structure (Fe) core-carbon shell; PEG-based coating) is studied. The greater part of the nanoparticles accumulated in the spleen and liver, a small amount in the lungs, and the minimum amount in the thymus. The structural changes in the lymphoid organs were minor and involved only the microcirculatory bed. Analysis of the peripheral blood showed manifest anemia, thrombocytopenia, and leukocytosis.

Keywords: biodistribution; iron-carbon nanoparticles; lymphoid organs.

MeSH terms

  • Animals
  • Carbon / metabolism
  • Carbon / pharmacokinetics*
  • Drug Carriers / pharmacokinetics*
  • Eosine Yellowish-(YS)
  • Hematoxylin
  • Histocytochemistry
  • Iron / metabolism
  • Iron / pharmacokinetics*
  • Liver / drug effects
  • Liver / ultrastructure
  • Lung / drug effects
  • Lung / ultrastructure
  • Magnetite Nanoparticles / chemistry*
  • Phosphatidylethanolamines / chemistry
  • Polyethylene Glycols / chemistry
  • Rats
  • Rats, Wistar
  • Spleen / drug effects
  • Spleen / ultrastructure
  • Thymus Gland / drug effects
  • Thymus Gland / ultrastructure
  • Tissue Distribution

Substances

  • 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy-poly(ethylene glycol 2000)
  • Drug Carriers
  • Magnetite Nanoparticles
  • Phosphatidylethanolamines
  • Polyethylene Glycols
  • Carbon
  • Iron
  • Eosine Yellowish-(YS)
  • Hematoxylin