Clearing the undergrowth: detection and quantification of low level impurities using 19F NMR

Pinelopi Moutzouri; Peter Kiraly; Andrew R Phillips; Steven R Coombes; Mathias Nilsson; Gareth A Morris

doi:10.1039/c6cc08836h

Clearing the undergrowth: detection and quantification of low level impurities using ¹⁹F NMR

Chem Commun (Camb). 2016 Dec 20;53(1):123-125. doi: 10.1039/c6cc08836h.

Authors

Pinelopi Moutzouri¹, Peter Kiraly¹, Andrew R Phillips², Steven R Coombes³, Mathias Nilsson¹, Gareth A Morris¹

Affiliations

¹ School of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, UK. g.a.morris@manchester.ac.uk.
² Pharmaceutical Sciences, AstraZeneca, Silk Road Business Park, Macclesfield, SK10 2NA, UK.
³ Pharmaceutical Technology and Development, AstraZeneca, Silk Road Business Park, Macclesfield, SK10 2NA, UK.

PMID: 27904900
DOI: 10.1039/c6cc08836h

Abstract

A new method for the analysis of low level impurities in sparsely fluorinated species allows measurement of clean high dynamic range ¹⁹F spectra, fully decoupled and free of interfering signals from ¹³C isotopomers.

Publication types

Research Support, Non-U.S. Gov't