Dataset of botulinum toxin A influence on interleukins under neuropathy

Magdalena Zychowska; Ewelina Rojewska; Wioletta Makuch; Siro Luvisetto; Flaminia Pavone; Sara Marinelli; Barbara Przewlocka; Joanna Mika

doi:10.1016/j.dib.2016.11.023

Dataset of botulinum toxin A influence on interleukins under neuropathy

Data Brief. 2016 Nov 15:9:1020-1023. doi: 10.1016/j.dib.2016.11.023. eCollection 2016 Dec.

Authors

Magdalena Zychowska¹, Ewelina Rojewska¹, Wioletta Makuch¹, Siro Luvisetto², Flaminia Pavone³, Sara Marinelli², Barbara Przewlocka¹, Joanna Mika¹

Affiliations

¹ Institute of Pharmacology, Polish Academy of Sciences, Department of Pain Pharmacology, Krakow, Poland.
² CNR, Institute of Cell Biology and Neurobiology, Rome, Italy.
³ CNR, Institute of Cell Biology and Neurobiology, Rome, Italy; IRCCS, Santa Lucia Foundation, Rome, Italy.

Abstract

Our data show that botulinum toxin A (BoNT/A) didn't influence motor functions in naïve and CCI-exposed rats, but diminished the neuropathic pain-related behavior. The results indicate that BoNT/A administration diminished the spinal Iba-1 positive cells activation and, in parallel, downregulated IL-1beta. Moreover, we observed that in DRG the protein level of pronociceptive factors (IL-1beta and IL-18) decreased and antinociceptive (IL-10 and IL-1RA) factors increased. Additionally, our behavioral analysis shows that chronic minocycline treatment together with a single BoNT/A injection in CCI-exposed rats has beneficial analgesic effects (M. Zychowska, E. Rojewska, W. Makuch, S. Luvisetto, F. Pavone, S. Marinelli, B. Przewlocka, J. Mika, 2016) [1].

Keywords: Botulinum neurotoxin A; Glia; Interleukins; Minocycline; Neuropathic pain model.