1 From the Department of Anaesthesia, Royal Free London NHS Trust, London, UK (SM), Department of Medicine, Thrombotic and Haemorrhagic Unit, University of Padova, Padova, Italy (PS), Department of Anaesthesiology and Intensive Care Medicine, Essen University Hospital, Essen (KG), Tem International, Munich, Germany (KG) and Department of Anaesthesiology, Aarhus University Hospital, Aarhus, Denmark (CF-E).