Polyinosinic-polycytidylic acid (poly(I:C)) attenuates imiquimod-induced skin inflammation in mice by increasing cutaneous PD-L1 expression

Exp Dermatol. 2017 Apr;26(4):346-348. doi: 10.1111/exd.13266. Epub 2017 Feb 27.

Authors

Kyung-Ah Cho¹, Ji-Yon Kim¹, Minhwa Park¹, Kyung Ho Lee², So-Youn Woo¹

Affiliations

¹ Department of Microbiology, School of Medicine, Ewha Womans University, Seoul, Korea.
² Department of Dermatology, College of Medicine, The Catholic University of Korea, Bucheon, Korea.

PMID: 27897321
DOI: 10.1111/exd.13266

No abstract available

Keywords: PD-L1; keratinocyte; poly(I:C); psoriasis.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Aminoquinolines
Animals
B7-H1 Antigen / metabolism*
Cell Line, Transformed
Dermatitis / immunology
Dermatitis / metabolism
Disease Models, Animal
Humans
Imiquimod
Keratinocytes / immunology*
Keratinocytes / metabolism
Mice
Poly I-C
Psoriasis / immunology*
Psoriasis / metabolism
Toll-Like Receptor 3 / metabolism

Substances

Aminoquinolines
B7-H1 Antigen
CD274 protein, human
Cd274 protein, mouse
TLR3 protein, human
Toll-Like Receptor 3
Poly I-C
Imiquimod