Haemodynamic and functional consequences of the iatrogenic atrial septal defect following Mitraclip therapy

E A Hart; K Zwart; A J Teske; M Voskuil; P R Stella; S A J Chamuleau; A O Kraaijeveld

doi:10.1007/s12471-016-0928-1

Haemodynamic and functional consequences of the iatrogenic atrial septal defect following Mitraclip therapy

Neth Heart J. 2017 Feb;25(2):137-142. doi: 10.1007/s12471-016-0928-1.

Authors

E A Hart¹, K Zwart², A J Teske², M Voskuil², P R Stella², S A J Chamuleau², A O Kraaijeveld²

Affiliations

¹ Department of Cardiology, division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands. e.a.hart-5@umcutrecht.nl.
² Department of Cardiology, division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.

Abstract

Percutaneous MitraClip placement for treatment of severe mitral regurgitation in high surgical risk patients is a commonly performed procedure and requires a transseptal puncture to reach the left atrium. The resulting iatrogenic atrial septal defect (iASD) is not routinely closed, yet the haemodynamic and functional consequences of a persisting defect are not fully understood. Despite positive effects such as acute left atrial pressure relief, persisting iASDs are associated with negative consequences, namely significant bidirectional shunting and subsequent worse clinical outcome. Percutaneous closure of the iASD may therefore be desirable in selected cases. In this review we discuss the available literature on this matter.

Keywords: Iatrogenic atrial septal defect; MitraClip; Mitral regurgitation.

Publication types

Review