Intravascular hemodynamics and coronary artery disease: New insights and clinical implications

Marina Zaromytidou; Gerasimos Siasos; Ahmet U Coskun; Michelle Lucier; Antonios P Antoniadis; Michail I Papafaklis; Konstantinos C Koskinas; Ioannis Andreou; Charles L Feldman; Peter H Stone

doi:10.1016/j.hjc.2016.11.019

Intravascular hemodynamics and coronary artery disease: New insights and clinical implications

Hellenic J Cardiol. 2016 Nov-Dec;57(6):389-400. doi: 10.1016/j.hjc.2016.11.019. Epub 2016 Nov 25.

Affiliations

¹ Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
² Mechanical and Industrial Engineering, Northeastern University, Boston, MA, United States.
³ Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States. Electronic address: pstone@partners.org.

PMID: 27894949
DOI: 10.1016/j.hjc.2016.11.019

Abstract

Intracoronary hemodynamics play a pivotal role in the initiation and progression of the atherosclerotic process. Low pro-inflammatory endothelial shear stress impacts vascular physiology and leads to the occurrence of coronary artery disease and its implications.

Keywords: Acute coronary syndromes; Atherosclerosis; Endothelial shear stress.

Publication types

Review

MeSH terms

Cardiac Imaging Techniques / methods
Coronary Artery Disease / diagnostic imaging*
Coronary Artery Disease / physiopathology*
Hemodynamics
Humans
Stress, Mechanical