1 Hannah Bower, Karolinska Institutet, Stockholm, Sweden; Magnus Björkholm, Karolinska University Hospital, Stockholm, Sweden; Paul W. Dickman, Karolinska Institutet, Stockholm, Sweden; Martin Höglund, University Hospital Uppsala, Uppsala, Sweden; Paul C. Lambert, Karolinska Institutet, Stockholm, Sweden, and University of Leicester, Leicester, United Kingdom; and Therese M.-L. Andersson, Karolinska Institutet, Stockholm, Sweden.