Abstract
Thirteen amidoderivatives of 3-methyl-3,4-dihydro-6-R-benzo-1,2,4-triazin-3-yl-acetic acids and of 3-methyl-3,4-dihydro-pyrido [3,2-e]/[3,4-e]-1,2,4-triazin- 3-yl-acetic acids were prepared and submitted to a wide pharmacological screening. The dihydrobenzotriazine and dihydropyridotriazine moieties were endowed with a wide pharmacogenic capacity; in fact, several compounds exhibited high antiinflammatory [(I c), (I d), (II d), (V f), (VI f)], diuretic [(I f), (I g), (I h)] and antihypertensive activities [(I d), (III d)], as well as minor effects on the C.N.S.
Publication types
-
English Abstract
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Acetates / chemical synthesis
-
Acetates / pharmacology
-
Animals
-
Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
-
Anticonvulsants
-
Antihypertensive Agents / chemical synthesis*
-
Chemical Phenomena
-
Chemistry
-
Diuresis / drug effects
-
Hemodynamics / drug effects
-
Magnetic Resonance Spectroscopy
-
Mice
-
Motor Activity / drug effects
-
Postural Balance / drug effects
-
Pyridines / chemical synthesis*
-
Pyridines / pharmacology
-
Rats
-
Sleep / drug effects
-
Spectrophotometry, Infrared
-
Spectrophotometry, Ultraviolet
-
Time Factors
-
Triazines / chemical synthesis*
-
Triazines / pharmacology
Substances
-
Acetates
-
Anti-Inflammatory Agents, Non-Steroidal
-
Anticonvulsants
-
Antihypertensive Agents
-
Pyridines
-
Triazines