Neuroimaging of Peptide-based Vaccine Therapy in Pediatric Brain Tumors: Initial Experience

Andre D Furtado; Rafael Ceschin; Stefan Blüml; Gary Mason; Regina I Jakacki; Hideho Okada; Ian F Pollack; Ashok Panigrahy

doi:10.1016/j.nic.2016.09.002

Neuroimaging of Peptide-based Vaccine Therapy in Pediatric Brain Tumors: Initial Experience

Neuroimaging Clin N Am. 2017 Feb;27(1):155-166. doi: 10.1016/j.nic.2016.09.002.

Authors

Andre D Furtado¹, Rafael Ceschin², Stefan Blüml³, Gary Mason⁴, Regina I Jakacki⁴, Hideho Okada⁵, Ian F Pollack⁶, Ashok Panigrahy⁷

Affiliations

¹ Department of Radiology, University of Pittsburgh, 3600 Forbes Avenue, Pittsburgh, PA 15213, USA.
² Department of Radiology, University of Pittsburgh, 3600 Forbes Avenue, Pittsburgh, PA 15213, USA; Department of Bioinformatics, University of Pittsburgh, 5607 Baum Boulevard, Suite 500, Pittsburgh, PA 15206, USA.
³ Department of Radiology, Children's Hospital of Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90007, USA.
⁴ Department of Pediatrics, University of Pittsburgh, 4401 Penn Avenue, Pittsburgh, PA 15224, USA.
⁵ Department of Neurosurgery, University of California, San Francisco, 505 Parnassus Avenue, M-779, San Francisco, CA 94143, USA.
⁶ Department of Neurosurgery, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA; Children's Hospital of Pittsburgh, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, University of Pittsburgh, 4401 Penn Avenue, Pittsburgh, PA 15224, USA.
⁷ Department of Radiology, University of Pittsburgh, 3600 Forbes Avenue, Pittsburgh, PA 15213, USA. Electronic address: panigrahya@upmc.edu.

Abstract

The potential benefits of peptide-based immunotherapy for pediatric brain tumors are under investigation. Treatment-related heterogeneity has resulted in radiographic challenges, including pseudoprogression. Conventional MR imaging has limitations in assessment of different forms of treatment-related heterogeneity, particularly regarding distinguishing true tumor progression from efficacious treatment responses. Advanced neuroimaging techniques, including diffusion magnetic resonance (MR), perfusion MR, and MR spectroscopy, may add value in the assessment of treatment-related heterogeneity. Observations suggest that recent delineation of specific response criteria for immunotherapy of adult brain tumors is likely relevant to the pediatric population and further validation in multicenter pediatric brain tumor peptide-based vaccine studies is warranted.

Keywords: MR spectroscopy; Pediatric brain tumors; Pseudoprogression; Vaccine therapy.

Publication types

Review

MeSH terms

Brain / diagnostic imaging
Brain / drug effects
Brain Neoplasms / diagnostic imaging*
Brain Neoplasms / drug therapy*
Child
Diffusion Magnetic Resonance Imaging
Humans
Immunotherapy, Active / methods*
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Neuroimaging / methods*
Peptides / therapeutic use*
Treatment Outcome

Substances

Peptides

Abstract

Publication types

MeSH terms

Substances

Grants and funding