Borna disease, a progressive meningoencephalomyelitis as a model for CD4+ T cell-mediated immunopathology in the brain

J A Richt; L Stitz; H Wekerle; R Rott

doi:10.1084/jem.170.3.1045

Borna disease, a progressive meningoencephalomyelitis as a model for CD4+ T cell-mediated immunopathology in the brain

J Exp Med. 1989 Sep 1;170(3):1045-50. doi: 10.1084/jem.170.3.1045.

Authors

J A Richt¹, L Stitz, H Wekerle, R Rott

Affiliation

¹ Institut für Virologie, Justus-Liebig-Universität Giessen, Federal Republic of Germany.

Abstract

A homogeneous T cell line NM1 with Borna disease (BD) virus reactivity could be established. The NM1 cells have been characterized as CD4+ T cells. Adoptive transfer revealed that this MHC class II-restricted immune cell is responsible for the immunopathological effect leading to BD, a progressive meningoencephalomyelitis.

MeSH terms

Animals
Antigens, Differentiation, T-Lymphocyte / analysis*
Borna Disease / immunology*
Borna disease virus / immunology
Disease Models, Animal
Meningoencephalitis / immunology*
Rats
Rats, Inbred Lew
T-Lymphocytes / immunology*

Substances

Antigens, Differentiation, T-Lymphocyte