What We Can Learn from "Super-responders"

Heart Fail Clin. 2017 Jan;13(1):225-232. doi: 10.1016/j.hfc.2016.07.018.

Abstract

This review discusses the state of the art of knowledge to help decision making in patients who are candidates for cardiac resynchronization therapy (CRT) and to analyze the long-term total and cardiac mortality, sudden death, and CRT with a defibrillator intervention rate, as well as the evolution of echocardiographic parameters in patients with a left ventricular (LV) ejection fraction of greater than 50% after CRT implantation. Owing to normalization of LV function in super-responders, the need for a persistent defibrillator backup is also considered.

Keywords: CRT; Cardiac resynchronization therapy; Left ventricular ejection fraction; Left ventricular function.

Publication types

  • Review

MeSH terms

  • Cardiac Resynchronization Therapy / adverse effects
  • Cardiac Resynchronization Therapy / methods*
  • Clinical Decision-Making / methods
  • Echocardiography
  • Electric Countershock / instrumentation*
  • Electric Countershock / statistics & numerical data
  • Evidence-Based Medicine
  • Heart Failure / mortality*
  • Heart Failure / physiopathology
  • Heart Failure / therapy*
  • Humans
  • Patient Selection
  • Recovery of Function
  • Survival Analysis
  • Treatment Outcome
  • Ventricular Dysfunction, Left / diagnostic imaging*
  • Ventricular Dysfunction, Left / etiology
  • Ventricular Dysfunction, Left / mortality
  • Ventricular Function, Left