Palladium-mediated in situ synthesis of an anticancer agent

Chem Commun (Camb). 2016 Dec 6;52(99):14212-14214. doi: 10.1039/c6cc08666g.

Abstract

As a novel prodrug activation strategy Pd(0) nanoparticles, entrapped within a modular polymeric support, were used in cell culture, to synthesise the anticancer agent PP-121 from two non-toxic precursors, thereby inducing cell death in the first example of in situ mediated drug synthesis.

MeSH terms

  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Cell Survival / drug effects
  • Dose-Response Relationship, Drug
  • Drug Screening Assays, Antitumor
  • Humans
  • Metal Nanoparticles / chemistry*
  • Molecular Structure
  • Palladium / chemistry*
  • Particle Size
  • Pyrazoles / chemical synthesis*
  • Pyrazoles / chemistry
  • Pyrazoles / pharmacology
  • Pyrimidines / chemical synthesis*
  • Pyrimidines / chemistry
  • Pyrimidines / pharmacology
  • Structure-Activity Relationship
  • Surface Properties
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • PP121 compound
  • Pyrazoles
  • Pyrimidines
  • Palladium