Autoclave Sterilization of PEDOT:PSS Electrophysiology Devices

Ilke Uguz; Mehran Ganji; Adel Hama; Atsunori Tanaka; Sahika Inal; Ahmed Youssef; Roisin M Owens; Pascale P Quilichini; Antoine Ghestem; Christophe Bernard; Shadi A Dayeh; George G Malliaras

doi:10.1002/adhm.201600870

Autoclave Sterilization of PEDOT:PSS Electrophysiology Devices

Adv Healthc Mater. 2016 Dec;5(24):3094-3098. doi: 10.1002/adhm.201600870. Epub 2016 Nov 25.

Affiliations

¹ Department of Bioelectronics, Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC, 13541, Gardanne, France.
² Department of Electrical and Computer Engineering, Jacobs School of Engineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0407, USA.
³ Inserm U1106, Institut de Neurosciences des Systèmes, Aix Marseille University, 13005, Marseille, France.

PMID: 27885829
DOI: 10.1002/adhm.201600870

Abstract

Autoclaving, the most widely available sterilization method, is applied to poly(3,4-ethylenedioxythiophene) doped with polystyrene sulfonate (PEDOT:PSS) electrophysiology devices. The process does not harm morphology or electrical properties, while it effectively kills E. coli intentionally cultured on the devices. This finding paves the way to widespread introduction of PEDOT:PSS electrophysiology devices to the clinic.

Keywords: conducting polymers; electrophysiology; organic bioelectronics.

MeSH terms

Bridged Bicyclo Compounds, Heterocyclic / chemistry*
Electrophysiology / methods
Escherichia coli / chemistry
Escherichia coli / growth & development
Polymers / chemistry*
Polystyrenes / chemistry*
Sterilization / methods

Substances

Bridged Bicyclo Compounds, Heterocyclic
Polymers
Polystyrenes
poly(3,4-ethylene dioxythiophene)
polystyrene sulfonic acid