Does anticoagulation therapy prevent thrombosis in coronary stent grafts?

Cardiovasc Interv Ther. 2017 Oct;32(4):405-408. doi: 10.1007/s12928-016-0443-8. Epub 2016 Nov 24.

Abstract

A polytetrafluoroethylene (PTFE)-covered stent was deployed for enlarging coronary aneurysms in a 73-year-old man. Optical coherence tomography (OCT) and coronary angioscopy performed 3 months later revealed naked stent struts and thin patches of red thrombi covering the PTFE membrane even under dual antiplatelet therapy (DAPT). After 5-month warfarin administration under DAPT, OCT and angioscopy showed a clear extinction of the thin patches of red thrombi on the PTFE membrane and stent struts, although most of the struts were still naked. The addition of anticoagulation therapy to DAPT may reduce thrombosis events in patients treated with PTFE-covered stents.

Keywords: Angioscopy; Anticoagulation therapy; Polytetrafluoroethylene (PTFE)-covered stent; Stent thrombosis.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Angioscopy
  • Anticoagulants / therapeutic use*
  • Biocompatible Materials
  • Blood Vessel Prosthesis Implantation / adverse effects*
  • Coronary Aneurysm / diagnostic imaging
  • Coronary Aneurysm / surgery*
  • Coronary Angiography
  • Coronary Vessels / diagnostic imaging
  • Drug Therapy, Combination
  • Humans
  • Male
  • Platelet Aggregation Inhibitors / therapeutic use*
  • Polytetrafluoroethylene
  • Stents / adverse effects*
  • Thrombosis / diagnosis
  • Thrombosis / etiology
  • Thrombosis / prevention & control*
  • Tomography, Optical Coherence
  • Warfarin / therapeutic use

Substances

  • Anticoagulants
  • Biocompatible Materials
  • Platelet Aggregation Inhibitors
  • Warfarin
  • Polytetrafluoroethylene