Increased serum hepcidin contributes to the anemia of chronic kidney disease in a murine model

Haematologica. 2017 Mar;102(3):e85-e88. doi: 10.3324/haematol.2016.150433. Epub 2016 Nov 24.

Authors

Mark R Hanudel¹, Maxime Rappaport², Victoria Gabayan³, Grace Jung³, Isidro B Salusky², Elizabeta Nemeth³, Tomas Ganz^{3

4}, Joshua Zaritsky⁵

Affiliations

¹ Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA mhanudel@mednet.ucla.edu.
² Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
³ Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
⁴ Department of Pathology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
⁵ Department of Pediatrics, A.I. duPont Hospital for Children, Wilmington, DE, USA.

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adenine / administration & dosage
Anemia / blood
Anemia / complications
Anemia / genetics*
Anemia / physiopathology
Animals
Blood Urea Nitrogen
Diet
Disease Models, Animal
Erythropoietin / blood
Erythropoietin / genetics*
Gene Expression Regulation
Hepcidins / blood
Hepcidins / deficiency
Hepcidins / genetics*
Humans
Iron / metabolism*
Kidney Tubules / drug effects
Kidney Tubules / metabolism*
Kidney Tubules / pathology
Mice
Mice, Inbred C57BL
Mice, Knockout
Renal Insufficiency, Chronic / blood
Renal Insufficiency, Chronic / complications
Renal Insufficiency, Chronic / genetics*
Renal Insufficiency, Chronic / physiopathology
Serum Amyloid A Protein / adverse effects
Serum Amyloid A Protein / metabolism

Substances

EPO protein, human
HAMP protein, human
Hepcidins
Serum Amyloid A Protein
Erythropoietin
Iron
Adenine

Grants and funding