The infectious hypoxia: occurrence and causes during Shigella infection

Ellen T Arena; Jean-Yves Tinevez; Giulia Nigro; Philippe J Sansonetti; Benoit S Marteyn

doi:10.1016/j.micinf.2016.10.011

The infectious hypoxia: occurrence and causes during Shigella infection

Microbes Infect. 2017 Mar;19(3):157-165. doi: 10.1016/j.micinf.2016.10.011. Epub 2016 Nov 21.

Authors

Ellen T Arena¹, Jean-Yves Tinevez², Giulia Nigro¹, Philippe J Sansonetti³, Benoit S Marteyn⁴

Affiliations

¹ Institut Pasteur, Unité de Pathogénie Microbienne Moléculaire, 28 rue du Dr Roux, 75724 Paris Cedex 15, France; INSERM Unité 1202, 28 rue du Dr Roux, 75724 Paris Cedex 15, France.
² Institut Pasteur, Citech, Imagopole, 28 rue du Dr Roux, 75724 Paris Cedex 15, France.
³ Institut Pasteur, Unité de Pathogénie Microbienne Moléculaire, 28 rue du Dr Roux, 75724 Paris Cedex 15, France; INSERM Unité 1202, 28 rue du Dr Roux, 75724 Paris Cedex 15, France; Collège de France, 11 Place Marcellin Berthelot, F-75231, Paris Cedex 05, France.
⁴ Institut Pasteur, Unité de Pathogénie Microbienne Moléculaire, 28 rue du Dr Roux, 75724 Paris Cedex 15, France; INSERM Unité 1202, 28 rue du Dr Roux, 75724 Paris Cedex 15, France; Gustave Roussy Cancer Campus, Laboratoire de Thérapie Cellulaire, 114 Rue Edouard Vaillant, 94800 Villejuif, France. Electronic address: marteyn@pasteur.fr.

PMID: 27884799
DOI: 10.1016/j.micinf.2016.10.011

Abstract

Hypoxia is defined as a tissue oxygenation status below physiological needs. During Shigella infection, an infectious hypoxia is induced within foci of infection. In this review, we discuss how Shigella physiology and virulence are modulated and how the main recruited immune cells, the neutrophils, adapt to this environment.

Keywords: Infectious hypoxia; Neutrophils; Shigella.

Publication types

Review

MeSH terms

Animals
Disease Models, Animal
Dysentery, Bacillary / microbiology*
Dysentery, Bacillary / pathology*
Humans
Hypoxia / pathology*
Immunity, Innate*
Neutrophils / immunology*
Shigella / immunology*
Shigella / pathogenicity*