Abstract
Hallucinogenic phenylalkylamine and N,N-dimethyltryptamine analogues are known to affect serotonergic systems both in vivo and in vitro. Using a rat stomach fundus model, the 5-HT receptor binding affinities of several of these analogues were determined and compared. The most behaviorally potent analogues examined, DOB, DOM, and 5-methoxy-N,N-dimethyltryptamine, were found to possess rather high affirmities (pA2 = 7.35, 7.12, and 7.08, respectively) for the 5-HT receptors of the model system.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amines / chemical synthesis*
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Amines / metabolism
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Amines / pharmacology
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Animals
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Female
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Hallucinogens / chemical synthesis*
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Hallucinogens / metabolism
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Hallucinogens / pharmacology
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In Vitro Techniques
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Male
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Muscle Contraction / drug effects
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Muscle, Smooth / drug effects
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N,N-Dimethyltryptamine / analogs & derivatives
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N,N-Dimethyltryptamine / chemical synthesis*
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N,N-Dimethyltryptamine / metabolism
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N,N-Dimethyltryptamine / pharmacology
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Rats
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Receptors, Serotonin / drug effects
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Receptors, Serotonin / metabolism*
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Stomach / drug effects
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Tryptamines / chemical synthesis*
Substances
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Amines
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Hallucinogens
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Receptors, Serotonin
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Tryptamines
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N,N-Dimethyltryptamine