Diastolic Dysfunction and Hypertension

Wilson Nadruz; Amil M Shah; Scott D Solomon

doi:10.1016/j.mcna.2016.08.013

Diastolic Dysfunction and Hypertension

Med Clin North Am. 2017 Jan;101(1):7-17. doi: 10.1016/j.mcna.2016.08.013.

Authors

Wilson Nadruz¹, Amil M Shah², Scott D Solomon³

Affiliations

¹ Cardiovascular Division, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA; Department of Internal Medicine, University of Campinas, Campinas, Brazil.
² Cardiovascular Division, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
³ Cardiovascular Division, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. Electronic address: ssolomon@bwh.harvard.edu.

PMID: 27884237
DOI: 10.1016/j.mcna.2016.08.013

Abstract

Left ventricular (LV) diastolic dysfunction (LVDD) is characterized by alterations in LV diastolic filling, and is a strong predictor of cardiovascular events and heart failure. Hypertension is the most important risk factor for LVDD in the community and promotes LVDD through several mechanisms, including hemodynamic overload and myocardial ischemia. Associated factors such as age, ethnicity, dietary sodium, obesity, diabetes mellitus, and chronic kidney disease also contribute to LVDD in hypertensive individuals. Blood pressure lowering using antihypertensive medications can improve LVDD; however, it remains unclear whether this improvement in LV diastolic function can improve cardiovascular outcomes.

Keywords: Diastolic dysfunction; Heart failure; Hypertension; Left ventricular hypertrophy.

Publication types

Review

MeSH terms

Diastole
Hemodynamics
Humans
Hypertension / complications
Hypertension / physiopathology*
Hypertrophy, Left Ventricular / etiology
Prognosis
Systole
Ventricular Dysfunction, Left / complications
Ventricular Dysfunction, Left / physiopathology*