LRRK2 contributes to monocyte dysregulation in Parkinson's disease

Acta Neuropathol Commun. 2016 Nov 24;4(1):123. doi: 10.1186/s40478-016-0396-2.
No abstract available

Keywords: Inflammation; LRRK2; Monocytes; Parkinson’s disease.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Animals
  • B-Lymphocytes / metabolism
  • GPI-Linked Proteins / metabolism
  • Humans
  • Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 / deficiency
  • Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 / genetics
  • Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 / metabolism*
  • Lipopolysaccharide Receptors / metabolism
  • Mice, Transgenic
  • Monocytes / metabolism*
  • Parkinsonian Disorders / metabolism*
  • Receptors, IgG / metabolism
  • Spleen / metabolism

Substances

  • FCGR3B protein, human
  • GPI-Linked Proteins
  • Lipopolysaccharide Receptors
  • Receptors, IgG
  • LRRK2 protein, human
  • Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
  • Lrrk2 protein, mouse