Severe Fever with Thrombocytopenia Syndrome Presenting with Hemophagocytic Lymphohistiocytosis

Jongmin Lee; Gyeongmin Jeong; Ji Hun Lim; Hawk Kim; Sun Whan Park; Won Ja Lee; Jae Bum Jun

doi:10.3947/ic.2016.48.4.338

Severe Fever with Thrombocytopenia Syndrome Presenting with Hemophagocytic Lymphohistiocytosis

Infect Chemother. 2016 Dec;48(4):338-341. doi: 10.3947/ic.2016.48.4.338. Epub 2016 Nov 11.

Authors

Jongmin Lee¹, Gyeongmin Jeong¹, Ji Hun Lim², Hawk Kim³, Sun Whan Park⁴, Won Ja Lee⁴, Jae Bum Jun⁵

Affiliations

¹ Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
² Department of Laboratory Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
³ Division of Hematology and Hematological Malignancies, Department of Hematology and Oncology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
⁴ Division of Arboviruses, Center for Immunology and Pathology, National Institute of Health, Korea Centers for Disease Control and Prevention, Cheongju, Korea.
⁵ Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea. uvgotletter@hanmail.net.

Abstract

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease caused by the newly discovered SFTS Bunyavirus, and there have been no case reports of SFTS patients presenting with hemophagocytic lymphohistiocytosis (HLH) in the English literature. We report a case of SFTS presenting with HLH in a 73-year-old immunocompetent male farmer. Although the patient had poor prognostic factors for SFTS, such as old age and central nervous system symptoms, he recovered fully with supportive care.

Keywords: Bunyavirus; Hemophagocytic lymphohistiocytosis; Severe fever with thrombocytopenia syndrome.

Publication types

Case Reports