Black Phosphorus Nanosheet-Based Drug Delivery System for Synergistic Photodynamic/Photothermal/Chemotherapy of Cancer

Wansong Chen; Jiang Ouyang; Hong Liu; Min Chen; Ke Zeng; Jianping Sheng; Zhenjun Liu; Yajing Han; Liqiang Wang; Juan Li; Liu Deng; You-Nian Liu; Shaojun Guo

doi:10.1002/adma.201603864

Black Phosphorus Nanosheet-Based Drug Delivery System for Synergistic Photodynamic/Photothermal/Chemotherapy of Cancer

Adv Mater. 2017 Feb;29(5). doi: 10.1002/adma.201603864. Epub 2016 Nov 24.

Authors

Wansong Chen^{1

2}, Jiang Ouyang², Hong Liu³, Min Chen², Ke Zeng², Jianping Sheng², Zhenjun Liu², Yajing Han², Liqiang Wang², Juan Li², Liu Deng², You-Nian Liu^{1

2}, Shaojun Guo^{4

5}

Affiliations

¹ State Key Laboratory for Powder Metallurgy, Central South University, Changsha, Hunan, 410083, P. R. China.
² College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan, 410083, P. R. China.
³ Aier Ophthalmic College, Central South University, Changsha, Hunan, 410083, P. R. China.
⁴ Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing, 100871, P. R. China.
⁵ BIC-ESAT, College of Engineering, Peking University, Beijing, 100871, P. R. China.

PMID: 27882622
DOI: 10.1002/adma.201603864

Abstract

A black phosphorus (BP)-based drug delivery system for synergistic photodynamic/photothermal/chemotherapy of cancer is constructed. As a 2D nanosheet, BP shows super high drug loading capacity and pH-/photoresponsive drug release. The intrinsic photothermal and photodynamic effects of BP enhance the antitumor activities. The synergistic photodynamic/photothermal/chemotherapy makes BP-based drug delivery system a multifunctional nanomedicine platform.

Keywords: black phosphorus nanosheets; chemotherapy; photodynamic therapy; photothermal therapy; synergistic therapy, drug delivery.

MeSH terms

Drug Delivery Systems
Drug Liberation
Humans
Neoplasms
Phosphorus / chemistry*
Phototherapy

Substances

Phosphorus