Duodenal ulcers are associated with a depletion of duodenal calcitonin gene-related peptide-like immunoreactivity in rats

S Evangelista; D Renzi; P Mantellini; C Surrenti; A Meli

doi:10.1016/0014-2999(89)90485-8

Duodenal ulcers are associated with a depletion of duodenal calcitonin gene-related peptide-like immunoreactivity in rats

Eur J Pharmacol. 1989 May 19;164(2):389-91. doi: 10.1016/0014-2999(89)90485-8.

Authors

S Evangelista¹, D Renzi, P Mantellini, C Surrenti, A Meli

Affiliation

¹ Pharmacology Department, Menarini Pharmaceuticals, Firenze, Italy.

PMID: 2788098
DOI: 10.1016/0014-2999(89)90485-8

Abstract

Calcitonin gene-related peptide-like immunoreactivity (CGRP-li) was decreased in duodenal samples from animals treated with ulcerogens such as dulcerozine, cysteamine or mepirizole. The degree of these experimental ulcers was inversely correlated with the levels of duodenal CGRP-li. These findings show that endogenous CGRP may play an important role in duodenal ulcerogenesis.

MeSH terms

Animals
Calcitonin Gene-Related Peptide
Cysteamine
Duodenal Ulcer / chemically induced
Duodenal Ulcer / metabolism*
Duodenum / metabolism*
Epirizole
Female
Neuropeptides / immunology
Neuropeptides / metabolism*
Pyrimidines
Rats
Rats, Inbred Strains

Substances

Neuropeptides
Pyrimidines
dulcerozine
Epirizole
Cysteamine
Calcitonin Gene-Related Peptide