Determination of Lamotrigine in Pharmaceutical Preparations by Adsorptive Stripping Voltammetry Using Screen Printed Electrodes

Olga Domínguez-Renedo; M Encarnación Burgoa Calvo; M Julia Arcos-Martínez

doi:10.3390/s8074201

Determination of Lamotrigine in Pharmaceutical Preparations by Adsorptive Stripping Voltammetry Using Screen Printed Electrodes

Sensors (Basel). 2008 Jul 15;8(7):4201-4212. doi: 10.3390/s8074201.

Authors

Olga Domínguez-Renedo¹, M Encarnación Burgoa Calvo², M Julia Arcos-Martínez³

Affiliations

¹ Departamento de Química, Área de Química Analítica, Facultad de Ciencias, Universidad de Burgos, Plaza Misael Bañuelos s/n, E-09001 Burgos, Spain. olgado@ubu.es.
² Departamento de Química, Área de Química Analítica, Facultad de Ciencias, Universidad de Burgos, Plaza Misael Bañuelos s/n, E-09001 Burgos, Spain. meburgoa@ubu.es.
³ Departamento de Química, Área de Química Analítica, Facultad de Ciencias, Universidad de Burgos, Plaza Misael Bañuelos s/n, E-09001 Burgos, Spain. jarcos@ubu.es.

Abstract

This paper describes a procedure that has been optimized for the determination of lamotrigine by Differential Pulse Adsorptive Stripping Voltammetry (DPAdSV) using carbon screen-printed electrodes (CSPE) and mercury coated carbon screen-printed electrodes. Selection of the experimental parameters was made using experimental design methodology. The detection limit found was 5.0 x 10^-6 M and 2.0 x 10^-6 M for the non modified and Hg modified CSPE, respectively. In terms of reproducibility, the precision of the above mentioned methods was calculated in %RSD values at 9.83% for CSPE and 2.73% for Hg-CSPE. The Hg-coated CSPEs developed in this work were successfully applied in the determination of lamotrigine in pharmaceutical preparations.

Keywords: differential pulse adsorptive stripping voltammetry.; lamotrigine; screen-printed electrodes.