Abstract
Selective agonists of μ1- and μ2-opioid receptors endomorphin-2 and endomorphin-1 injected intravenously in a dose of 4500 nmol/kg in 5 min before coronary blood flow resumption had no effect on cardiac reperfusion damage. Consequently, μ1- and μ2-opioid receptors are not involved in the regulation of heart tolerance to reperfusion injury. Nonselective opioid receptor agonist β-endorphin (100 nmol/kg) also did not affect heart tolerance to the pathogenic effect of reperfusion.
Keywords:
arrhythmias; heart; myocardial infarction; opioids; postconditioning.
MeSH terms
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Analgesics, Opioid / pharmacology*
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Animals
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Arrhythmias, Cardiac / metabolism*
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Arrhythmias, Cardiac / physiopathology
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Blood Pressure / drug effects
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Coronary Occlusion
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Coronary Vessels / surgery
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Ischemic Postconditioning
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Male
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Myocardial Reperfusion Injury / metabolism*
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Myocardial Reperfusion Injury / physiopathology
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Myocardium / metabolism
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Myocardium / pathology
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Oligopeptides / pharmacology*
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Rats
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Rats, Wistar
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Receptors, Opioid, mu / agonists
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Receptors, Opioid, mu / metabolism
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beta-Endorphin / pharmacology*
Substances
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Analgesics, Opioid
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Oligopeptides
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Receptors, Opioid, mu
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endomorphin 1
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endomorphin 2
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beta-Endorphin