Endomorphins and β-Endorphin Do Not Affect Heart Tolerance to the Pathogenic Effect of Reperfusion

Bull Exp Biol Med. 2016 Nov;162(1):23-26. doi: 10.1007/s10517-016-3535-7. Epub 2016 Nov 23.

Abstract

Selective agonists of μ1- and μ2-opioid receptors endomorphin-2 and endomorphin-1 injected intravenously in a dose of 4500 nmol/kg in 5 min before coronary blood flow resumption had no effect on cardiac reperfusion damage. Consequently, μ1- and μ2-opioid receptors are not involved in the regulation of heart tolerance to reperfusion injury. Nonselective opioid receptor agonist β-endorphin (100 nmol/kg) also did not affect heart tolerance to the pathogenic effect of reperfusion.

Keywords: arrhythmias; heart; myocardial infarction; opioids; postconditioning.

MeSH terms

  • Analgesics, Opioid / pharmacology*
  • Animals
  • Arrhythmias, Cardiac / metabolism*
  • Arrhythmias, Cardiac / physiopathology
  • Blood Pressure / drug effects
  • Coronary Occlusion
  • Coronary Vessels / surgery
  • Ischemic Postconditioning
  • Male
  • Myocardial Reperfusion Injury / metabolism*
  • Myocardial Reperfusion Injury / physiopathology
  • Myocardium / metabolism
  • Myocardium / pathology
  • Oligopeptides / pharmacology*
  • Rats
  • Rats, Wistar
  • Receptors, Opioid, mu / agonists
  • Receptors, Opioid, mu / metabolism
  • beta-Endorphin / pharmacology*

Substances

  • Analgesics, Opioid
  • Oligopeptides
  • Receptors, Opioid, mu
  • endomorphin 1
  • endomorphin 2
  • beta-Endorphin