Pulmonary complications after abdominal surgery in patients with mild-to-moderate chronic obstructive pulmonary disease

Int J Chron Obstruct Pulmon Dis. 2016 Nov 9:11:2785-2796. doi: 10.2147/COPD.S119372. eCollection 2016.

Abstract

Postoperative pulmonary complications (PPCs) are one of the most important causes of postoperative morbidity and mortality after abdominal surgery. Although chronic obstructive pulmonary disease (COPD) has been considered a risk factor for PPCs, it remains unclear whether mild-to-moderate COPD is a risk factor. This retrospective cohort study included 387 subjects who underwent abdominal surgery with general anesthesia in a tertiary referral hospital. PPCs included pneumonia, pulmonary edema, pulmonary thromboembolism, atelectasis, and acute exacerbation of COPD. Among the 387 subjects, PPCs developed in 14 (12.0%) of 117 patients with mild-to-moderate COPD and in 13 (15.1%) of 86 control patients. Multiple logistic regression analysis revealed that mild-to-moderate COPD was not a significant risk factor for PPCs (odds ratio [OR] =0.79; 95% confidence interval [CI] =0.31-2.03; P=0.628). However, previous hospitalization for respiratory problems (OR =4.20; 95% CI =1.52-11.59), emergency surgery (OR =3.93; 95% CI =1.75-8.82), increased amount of red blood cell (RBC) transfusion (OR =1.09; 95% CI =1.05-1.14 for one pack increase of RBC transfusion), and laparoscopic surgery (OR =0.41; 95% CI =0.18-0.93) were independent predictors of PPCs. These findings suggested that mild-to-moderate COPD may not be a significant risk factor for PPCs after abdominal surgery.

Keywords: abdominal surgery; postoperative care; postoperative complications; postoperative pulmonary complications; risk factor; spirometry.

MeSH terms

  • Abdomen / surgery*
  • Aged
  • Female
  • Forced Expiratory Volume
  • Humans
  • Laparotomy / adverse effects*
  • Laparotomy / mortality
  • Logistic Models
  • Lung / physiopathology*
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Odds Ratio
  • Postoperative Complications / diagnosis
  • Postoperative Complications / etiology*
  • Postoperative Complications / mortality
  • Postoperative Complications / physiopathology
  • Pulmonary Disease, Chronic Obstructive / complications*
  • Pulmonary Disease, Chronic Obstructive / diagnosis
  • Pulmonary Disease, Chronic Obstructive / mortality
  • Pulmonary Disease, Chronic Obstructive / physiopathology
  • Respiratory Tract Diseases / diagnosis
  • Respiratory Tract Diseases / etiology*
  • Respiratory Tract Diseases / mortality
  • Respiratory Tract Diseases / physiopathology
  • Retrospective Studies
  • Risk Assessment
  • Risk Factors
  • Severity of Illness Index
  • Tertiary Care Centers
  • Treatment Outcome
  • Vital Capacity