Iodine-125 Interstitial Brachytherapy for Pediatric Desmoid-Type Fibromatosis of the Head and Neck: A Case Report

J Oral Maxillofac Surg. 2017 Apr;75(4):768.e1-768.e11. doi: 10.1016/j.joms.2016.10.026. Epub 2016 Oct 29.

Abstract

Desmoid-type fibromatosis (DF) is a locally aggressive benign soft tissue tumor. It is rarely observed in the head and neck region and is particularly uncommon in the parotid gland. This report describes the case of a 32-month-old girl with DF of the head and neck. The tumor was resected with gross residual tumors. Recurrence occurred 3 months later and then the patient was treated with iodine-125 interstitial brachytherapy. The tumor was completely absent 6 months after brachytherapy. No recurrence was found 60 months after brachytherapy during follow-up. No severe toxicities or growth abnormalities were observed. Very-low-dose rate brachytherapy as the sole modality could be a reasonable alternative for the treatment of inoperable DF of the head and neck, which avoids the risk of cosmetic deformity caused by surgery, especially in pediatric patients. In addition, long-term follow-up is recommended.

Publication types

  • Case Reports

MeSH terms

  • Brachytherapy / methods*
  • Child, Preschool
  • Female
  • Fibromatosis, Aggressive / radiotherapy*
  • Fibromatosis, Aggressive / surgery*
  • Head and Neck Neoplasms / radiotherapy*
  • Head and Neck Neoplasms / surgery*
  • Humans
  • Iodine Radioisotopes / therapeutic use*
  • Magnetic Resonance Imaging
  • Tomography, X-Ray Computed

Substances

  • Iodine Radioisotopes