High burden of antimicrobial drug resistance in Asia

Chi-Cheng Lai; Kyungwon Lee; Yonghong Xiao; Norazah Ahmad; Balaji Veeraraghavan; Visanu Thamlikitkul; Paul Ananth Tambyah; R H H Nelwan; Atef M Shibl; Jiunn-Jong Wu; Wing-Hong Seto; Po-Ren Hsueh

doi:10.1016/j.jgar.2014.02.007

High burden of antimicrobial drug resistance in Asia

J Glob Antimicrob Resist. 2014 Sep;2(3):141-147. doi: 10.1016/j.jgar.2014.02.007. Epub 2014 Mar 28.

Authors

Affiliations

¹ Department of Intensive Care Medicine, Chi-Mei Medical Center, Liouying, Tainan, Taiwan.
² Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, South Korea.
³ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
⁴ Institute for Medical Research, Kuala Lumpur, Malaysia.
⁵ Christian Medical College & Hospital, Vellore, India.
⁶ Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
⁷ Department of Internal Medicine, National University Hospital, Singapore.
⁸ Division of Tropical and Infectious Diseases, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
⁹ King Saud University, Riyadh, Saudi Arabia.
¹⁰ Department of Medical Laboratory Science and Biotechnology, National Cheng-Kung University, Tainan, Taiwan.
¹¹ Hospital Authority, Hong Kong, China.
¹² Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, No. 7 Chung-Shan South Road, Taipei 100, Taiwan. Electronic address: hsporen@ntu.edu.tw.

PMID: 27873720
DOI: 10.1016/j.jgar.2014.02.007

Abstract

The rapid development of antimicrobial resistance among micro-organisms is a serious public health concern. Moreover, the dissemination of antibiotic-resistant bacteria makes this issue a global problem, and Asia is no exception. For example, since New Delhi metallo-β-lactamase (NDM)-producing Enterobacteriaceae were identified in India, further spread of NDM has become a worldwide threat. However, the epidemiology of antibiotic-resistant bacteria in Asia may be different to other regions, and clinical condition may be worse than in western countries. Antibiotic-resistant bacteria, including community-acquired and hospital-acquired meticillin-resistant Staphylococcus aureus (MRSA), vancomycin-intermediate S. aureus (VISA), vancomycin-resistant enterococci, macrolide- and penicillin-resistant Streptococcus pneumoniae, extend-spectrum β-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae, carbapenem-resistant Enterobacteriaceae, and multidrug-resistant Pseudomonas aeruginosa and Acinetobacter spp., are becoming prevalent in many countries in Asia. Moreover, the prevalence of each antibiotic-resistant bacterium in each country is not identical. This review provides useful information regarding the critical condition of antibiotic resistance in Asia and emphasises the importance of continuous surveillance of resistance data.

Keywords: Antimicrobial resistance; Asia; Carbapenem-resistant Enterobacteriaceae; Meticillin-resistant Staphylococcus aureus; Vancomycin-resistant enterococci.

Publication types

Review