Treatment of extensively drug-resistant Gram-negative infections in critically ill patients: Outcome of a consensus meeting at the 13th Asia-Pacific Congress of Clinical Microbiology and Infection, October 2012

Paul Anantharajah Tambyah; Gabriel Levy Hara; George L Daikos; Matthew E Falagas; Teresita Mazzei; Johan W Mouton; Andrea Novelli; Baiyi Chen; Minggui Wang; Wen-Chien Ko; Taisheng Li; Xinjian Fan; Ursula Theuretzbacher

doi:10.1016/j.jgar.2013.04.002

Treatment of extensively drug-resistant Gram-negative infections in critically ill patients: Outcome of a consensus meeting at the 13th Asia-Pacific Congress of Clinical Microbiology and Infection, October 2012

J Glob Antimicrob Resist. 2013 Sep;1(3):117-122. doi: 10.1016/j.jgar.2013.04.002. Epub 2013 May 23.

Authors

Affiliations

¹ National University of Singapore, 1E Kent Ridge Road, Singapore 119228, Singapore.
² Infectious Diseases Unit, Hospital Carlos G. Durand, Buenos Aires, Argentina.
³ First Department of Propaedeutic Medicine, Athens University School of Medicine, Athens, Greece.
⁴ Alfa Institute of Biomedical Sciences (AIBS), Athens, Greece; Tufts University School of Medicine, Boston, MA, USA.
⁵ Department of Health Sciences, Clinical Pharmacology and Oncology Section, University of Florence, Florence, Italy.
⁶ Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
⁷ The First Hospital of China Medical University, Shenyang, China.
⁸ Huashan Hospital, Fudan University, 12 M. Wulumuqi Road, Shanghai 200040, China.
⁹ Department of Internal Medicine, National Cheng Kung University Medical College and Hospital, Taiwan.
¹⁰ Peking Union Medical College Hospital, Beijing, China.
¹¹ West China School of Medicine, West China Hospital, Sichuan University, Chengdu, China.
¹² Center for Anti-Infective Agents, Eckpergasse 13, 1180 Vienna, Austria. Electronic address: utheuretzbacher@cefaia.com.

PMID: 27873621
DOI: 10.1016/j.jgar.2013.04.002

Abstract

Infections caused by multidrug-resistant and extensively drug-resistant Gram-negative bacilli are increasingly challenging to manage in hospitals and long term-care facilities worldwide. As the therapeutic options are limited, the International Society of Chemotherapy in collaboration with the Asia-Pacific Society of Clinical Microbiology and Immunology organised a consensus conference as part of the 13th Asia-Pacific Congress of Clinical Microbiology and Infection. A panel of international experts from Europe, the Americas and Asia were convened to discuss the issues of therapeutic options for the management of these difficult-to-treat pathogens.

Keywords: Aminoglycoside; Carbapenems; Colistin; Extensively drug-resistant; Gram-negative bacteria; Resistance; Tigecycline.

Publication types

Review