Thyroid metastasis from lung adenocarcinoma with EML4-ALK rearrangement

BMJ Case Rep. 2016 Nov 21:2016:bcr2016217541. doi: 10.1136/bcr-2016-217541.

Abstract

Thyroid metastases from lung cancer are very rare. A woman aged 42 years with a tumour in the lower lobe of the right lung was diagnosed as having lung adenocarcinoma positive for echinoderm microtubule-associated proteinlike 4-anaplastic lymphoma kinase. Positron emission tomography demonstrated fluorodeoxyglucose accumulation in the lower lobe of the right lung, the right thyroid lobe and both adrenal glands. We performed fine-needle aspiration biopsy (FNAB) and used reverse transcriptase-PCR (RT-PCR) to diagnose the patient as having metastatic lung adenocarcinoma to the thyroid gland. We believe that FNAB combined with RT-PCR can be an effective method for diagnosing metastatic lung adenocarcinoma to the thyroid gland.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / diagnosis
  • Adenocarcinoma / pathology*
  • Adenocarcinoma / secondary*
  • Adult
  • Biopsy, Fine-Needle
  • Female
  • Humans
  • Lung Neoplasms / pathology*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Thyroid Neoplasms / diagnosis
  • Thyroid Neoplasms / secondary*