Biodegradable polymeric nanoparticles containing gold nanoparticles and Paclitaxel for cancer imaging and drug delivery using photoacoustic methods

Yanjie Wang; Eric M Strohm; Yang Sun; Zhaoxia Wang; Yuanyi Zheng; Zhigang Wang; Michael C Kolios

doi:10.1364/BOE.7.004125

Biodegradable polymeric nanoparticles containing gold nanoparticles and Paclitaxel for cancer imaging and drug delivery using photoacoustic methods

Biomed Opt Express. 2016 Sep 16;7(10):4125-4138. doi: 10.1364/BOE.7.004125. eCollection 2016 Oct 1.

Authors

Yanjie Wang¹, Eric M Strohm¹, Yang Sun², Zhaoxia Wang³, Yuanyi Zheng⁴, Zhigang Wang², Michael C Kolios¹

Affiliations

¹ Physics Department, Ryerson University, 350 Victoria St., Toronto, Ontario M5B 2K3, Canada; Institute for Biomedical Engineering, Science and Technology (iBEST), a partnership between Ryerson University and St. Michael's Hospital, 30 Bond St., Toronto, Ontario, M5B 1T8, Canada; Keenan Research Centre for Biomedical Science of St. Michael's Hospital, 30 Bond St., Toronto, Ontario, M5B 1T8, Canada.
² Institute of Ultrasound Imaging, Second Affiliated Hospital, Chongqing Medical University, 76 Linjiang Rd., Chongqing, 400010, China.
³ Department of Ultrasound, Children's Hospital, Affiliated to Chongqing Medical University, No.136, Zhongshan No.2 Rd., Yuzhong District, Chongqing 400014, China.
⁴ Ultrasound Department, Sixth affiliated hospital of Shanghai Jiaotong University, 600 Yishan Rd., Xuhui District, Shanghai, 200133, China.

Abstract

In this study, optical-triggered multifunctional theranostic agents for photoacoustic/fluorescent imaging and cancer therapy have been developed. This system consists of a perfluorohexane liquid and gold nanoparticles (GNPs) in the core, stabilized by a Poly (lactide-co-glycolic acid) (PLGA) polymer shell. When cancer cells containing PLGA-GNPs were exposed to laser pulses, cell viability decreased due to the vaporization of the particles in and around the cells. The particle chemo drug loading and delivery capacity was also investigated in vitro experiments. These particles show potential as photoacoustic imaging and therapy agents for future clinical translation in cancer therapy.

Keywords: (160.1435) Biomaterials; (160.4236) Nanomaterials; (170.2520) Fluorescence microscopy; (170.3880) Medical and biological imaging; (170.5120) Photoacoustic imaging.