PRKAG3 polymorphisms associated with sporadic Wolff-Parkinson-White syndrome among a Taiwanese population

Ken-Pen Weng; Yeong-Seng Yuh; Shih-Hui Huang; Hsiang-Chiang Hsiao; Huang-Wei Wu; Jen-Hung Chien; Bo-Hau Chen; Shih-Ming Huang; Kuang-Jen Chien; Luo-Ping Ger

doi:10.1016/j.jcma.2016.08.008

PRKAG3 polymorphisms associated with sporadic Wolff-Parkinson-White syndrome among a Taiwanese population

J Chin Med Assoc. 2016 Dec;79(12):656-660. doi: 10.1016/j.jcma.2016.08.008. Epub 2016 Nov 17.

Authors

Affiliations

¹ Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, ROC; Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC. Electronic address: kenpenweng@yahoo.com.tw.
² Department of Pediatrics, Cheng Hsin General Hospital, Taipei, Taiwan, ROC.
³ Department of Nursing, Fooyin University, Kaohsiung, Taiwan, ROC.
⁴ Division of Cardiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, ROC.
⁵ Department of Pediatrics, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan, ROC.
⁶ Department of Pediatrics, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan, ROC.
⁷ Department of Pediatrics, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan, ROC.
⁸ Department of Pediatrics, Kaohsiung Municipal United Hospital, Kaohsiung, Taiwan, ROC.
⁹ Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, ROC.
¹⁰ Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, ROC; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan, ROC.

PMID: 27866917
DOI: 10.1016/j.jcma.2016.08.008

Abstract

Background: The aim of this study was to investigate whether mutation in AMP-activated protein kinase (AMPK) subunit genes (PRKAG3-230) is associated with sporadic, isolated Wolff-Parkinson-White (WPW) syndrome.

Methods: This study consisted of 87 patients with symptomatic WPW syndrome and 93 healthy controls. PRKAG3-230 genotypes were determined using real-time polymerase chain reaction assay. Genotype and allele frequencies of PRKAG3-230 between patients with WPW syndrome and healthy controls were ascertained using chi-square test or Fisher exact test when appropriate.

Results: PRKAG3-230 were genotyped in 87 patients (53 men and 34 women; age=24.4±18.0 years) with WPW syndrome and 93 healthy controls (57 men and 36 women; age=16.8±4.2 years). There were no significant differences between the two groups in terms of age and sex. The patients with CG and CG+CC genotypes had a significantly increased risk of WPW syndrome compared with those with GG genotype [odds ratio (OR)=1.99, 95% confidence interval (CI)=1.01-3.89, p=0.045; OR=1.99, 95% CI=1.04-3.78, p=0.037, respectively]. The allelic types were not associated with the risk of WPW syndrome. The patients with manifest type with CG and CG+CC genotypes had a significantly increased risk of WPW syndrome compared with those with GG genotype (OR=2.86, 95% CI=1.16-7.05, p=0.022; OR=2.84, 95% CI=1.19-6.80, p=0.019, respectively). The patients with right-side accessory pathways with CG and CG+CC genotypes had a significantly increased risk of WPW syndrome compared with those with GG genotype (OR=3.07, 95% CI=1.25-7.51, p=0.014; OR=2.84, 95% CI=1.19-6.80, p=0.019, respectively). The allelic types were not associated with the risk of WPW types and locations.

Conclusion: This study shows that PRKAG3-230 may be associated with sporadic WPW syndrome among a Taiwanese population. Further studies are warranted to elucidate the role of mutations in AMPK subunit genes other than PRKAG3-230 in sporadic WPW syndrome.

Keywords: PRKAG3-230 (rs692243); Wolff–Parkinson–White syndrome; genetics; tachycardia.

MeSH terms

AMP-Activated Protein Kinases / genetics*
Adolescent
Adult
Child
Gene Frequency
Genotype
Humans
Male
Wolff-Parkinson-White Syndrome / genetics*
Young Adult

Substances

PRKAG3 protein, human
AMP-Activated Protein Kinases