B-cell lymphoma 2 interacting mediator of cell death (BIM) plays an important role in the progress of cell apoptosis. The lowering expression level or functional defect of which may have an negative effect on the efficacy of anticancer drugs and the prognosis of postoperative patients with non-small cell lung cancer (NSCLC). This review aims to summarize the structure and function of BIM, as well as the relationship between BIM and the therapeutic efficacy of NSCLC.
B细胞淋巴瘤-2促细胞凋亡（B-cell lymphoma 2 interacting mediator of cell death, BIM）基因作为抑癌基因，在调控细胞凋亡中起重要作用。在非小细胞肺癌（non-small cell lung cancer, NSCLC）中，BIM表达水平的下调或功能缺陷会降低酪氨酸激酶抑制剂（tyrosine kinase inhibitors, TKIs）及化疗药物的疗效并影响术后患者的预后。本文将对BIM的结构、功能以及BIM在NSCLC治疗中的作用及意义进行介绍。.