As the leading cause of morbidity and cancer related-death worldwide, lung cancer has a serious threat to human health. Exosomes are nanoscale lipid membrane vesicles derived from multivesicles, which containing active biomolecules including proteins, lipids, nucleic acids and etc. Exosomes play important roles in lung cancer initiation and progression by promoting the formation of tumor microenvironment, enhancing tumor invasive and metastasis capability, leading to immunosuppression and resistance to chemoradiotherapy, and also have the application value in early diagnosis and treatment. This review summarizes the research progress of exosomes in tumor initiation and progression, and its roles in diagnosis and treatment of lung cancer.
肺癌是全球范围内发病率及死亡率最高的恶性肿瘤，其严重威胁着人类健康。外泌体（exosomes）是起源于多泡体的纳米级脂质膜囊泡，其内含有蛋白质、脂质、核酸等多种活性生物分子。外泌体在肺癌的发生与演进中发挥重要作用，其可促进肺癌微环境形成，增强肿瘤侵袭与转移能力，参与肿瘤免疫抑制及肿瘤放化疗抵抗，且对肺癌的早期诊断和治疗具有应用价值。本文将对外泌体在肺癌发生、发展、诊断及治疗中的研究进展进行综述。.