Molecular Imaging and Precision Medicine in Prostate Cancer

PET Clin. 2017 Jan;12(1):83-92. doi: 10.1016/j.cpet.2016.08.004. Epub 2016 Sep 9.

Abstract

The aim of the present review is to discuss about the role of new probes for molecular imaging in the evaluation of prostate cancer (PCa). This review focuses particularly on the role of new promising radiotracers for the molecular imaging with PET/computed tomography in the detection of PCa recurrence. The role of these new imaging techniques to guide lesion-target therapies and the potential application of these molecular probes as theranostics agents is discussed. Finally, the molecular mechanisms underlying resistance to castration in PCa and the maintenance of active androgen receptor are discussed.

Keywords: (68)Ga-PSMA PET/CT; Androgen receptor; Biochemical relapse; Castrate resistant prostate cancer; Prostate cancer.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor
  • Humans
  • Male
  • Molecular Imaging*
  • Molecular Targeted Therapy
  • Positron Emission Tomography Computed Tomography / methods*
  • Precision Medicine*
  • Predictive Value of Tests
  • Prostatic Neoplasms / diagnostic imaging*
  • Prostatic Neoplasms / therapy*
  • Radiopharmaceuticals
  • Receptors, Androgen / physiology

Substances

  • Biomarkers, Tumor
  • Radiopharmaceuticals
  • Receptors, Androgen