Abstract
Chronic disseminated candidiasis (CDC) is a rare and difficult-to-treat invasive fungal disease occurring mainly after prolonged and profound neutropenia. We describe the case of a 59-year-old man successfully treated with thalidomide for CDC recurrences after an autologous transplantation. We add evidence of the effectiveness of immunomodulatory drugs to manage inflammatory reconstitution immune syndrome-related refractory CDC.
Keywords:
Candida; chronic disseminated candidiasis; immune reconstitution inflammatory syndrome; stem cell transplantation.
© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
MeSH terms
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Antifungal Agents / administration & dosage
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Antifungal Agents / therapeutic use
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Bone Marrow Transplantation / adverse effects*
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Candida albicans / isolation & purification*
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Candidiasis / diagnostic imaging
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Candidiasis / drug therapy*
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Candidiasis / immunology
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Chronic Disease
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Fluconazole / administration & dosage
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Fluconazole / therapeutic use
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Glucocorticoids / administration & dosage
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Glucocorticoids / adverse effects
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Glucocorticoids / therapeutic use*
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Hodgkin Disease / complications
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Hodgkin Disease / surgery*
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Humans
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Immune Reconstitution Inflammatory Syndrome / diagnostic imaging
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Immune Reconstitution Inflammatory Syndrome / drug therapy*
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Immune Reconstitution Inflammatory Syndrome / immunology
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Immunosuppressive Agents / administration & dosage
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Immunosuppressive Agents / adverse effects
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Immunosuppressive Agents / therapeutic use*
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Magnetic Resonance Imaging
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Male
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Middle Aged
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Neutropenia / complications
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Positron Emission Tomography Computed Tomography
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Recurrence
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Thalidomide / administration & dosage
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Thalidomide / adverse effects
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Thalidomide / therapeutic use*
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Transplantation, Homologous / adverse effects
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Treatment Outcome
Substances
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Antifungal Agents
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Glucocorticoids
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Immunosuppressive Agents
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Thalidomide
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Fluconazole