The paper deals with the isolation and identification of the constituents of Cornus officinalis Sieb. et Zucc. leaves. There was isolated β-sitosterol from petroleum ether extract, glucose and saccharose from methanolic extract and gallic acid, quercetin and quercetin-3-O-glucoside (isoquercitrin) from aqueous-methanolic extract. Isolates were identified by physico-chemical data, and by comparing with authentic samples and literature data. The compounds I - V were isolated from the leaves of Cornus officinalis Sieb. et Zucc. for the first time.Key words: Cornus officinalis Sieb. et Zucc. Cornaceae petroleum ether extract methanolic extract aqueous-methanolic extract.