Rapid Continuous Multimaterial Extrusion Bioprinting

Wanjun Liu; Yu Shrike Zhang; Marcel A Heinrich; Fabio De Ferrari; Hae Lin Jang; Syeda Mahwish Bakht; Mario Moisés Alvarez; Jingzhou Yang; Yi-Chen Li; Grissel Trujillo-de Santiago; Amir K Miri; Kai Zhu; Parastoo Khoshakhlagh; Gyan Prakash; Hao Cheng; Xiaofei Guan; Zhe Zhong; Jie Ju; Geyunjian Harry Zhu; Xiangyu Jin; Su Ryon Shin; Mehmet Remzi Dokmeci; Ali Khademhosseini

doi:10.1002/adma.201604630

Rapid Continuous Multimaterial Extrusion Bioprinting

Adv Mater. 2017 Jan;29(3):10.1002/adma.201604630. doi: 10.1002/adma.201604630. Epub 2016 Nov 17.

Authors

Wanjun Liu^{1

2

3}, Yu Shrike Zhang^{1

2

4}, Marcel A Heinrich^{1

2

5}, Fabio De Ferrari^{1

2

6}, Hae Lin Jang^{1

2}, Syeda Mahwish Bakht^{1

2

7}, Mario Moisés Alvarez^{1

2

8

9}, Jingzhou Yang^{1

2

10}, Yi-Chen Li^{1

2}, Grissel Trujillo-de Santiago^{1

2

8

9}, Amir K Miri^{1

2}, Kai Zhu^{1

2

11

12}, Parastoo Khoshakhlagh^{1

2

4}, Gyan Prakash^{1

2}, Hao Cheng^{1

2}, Xiaofei Guan^{1

2}, Zhe Zhong^{1

2}, Jie Ju^{1

2}, Geyunjian Harry Zhu^{1

2

13}, Xiangyu Jin³, Su Ryon Shin^{1

2

4}, Mehmet Remzi Dokmeci^{1

2

4}, Ali Khademhosseini^{1

2

4

14

15}

Affiliations

¹ Biomaterials Innovation Research Center, Division of Engineering in Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
² Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
³ Key Laboratory of Textile Science and Technology, College of Textiles, Donghua University, Shanghai, 201620, China.
⁴ Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA.
⁵ MIRA Institute of Biomedical Technology and Technical Medicine, Department of Developmental BioEngineering, University of Twente, Enschede, 7500AE, The Netherlands.
⁶ Department of Electronics and Telecommunications, Politecnico di Torino, Torino, 10129, Italy.
⁷ COMSATS Institute of Information and Technology, Islamabad, 45550, Pakistan.
⁸ Microsystems Technologies Laboratories, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
⁹ Centro de Biotecnología-FEMSA, Tecnológico de Monterrey at Monterrey, Monterrey, Nuevo León, CP, 64849, Mexico.
¹⁰ School of Mechanical and Chemical Engineering, University of Western Australia, Perth, WA, 6009, Australia.
¹¹ Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, P. R. China.
¹² Shanghai Institute of Cardiovascular Disease, Shanghai, 200032, P. R. China.
¹³ Department of Polymer Engineering, University of Akron, Akron, OH, 44325-0301, USA.
¹⁴ Department of Bioindustrial Technologies, College of Animal Bioscience and Technology, Konkuk University, Seoul, 143-701, Republic of Korea.
¹⁵ Department of Physics, King Abdulaziz University, Jeddah, 21569, Saudi Arabia.

Abstract

The development of a multimaterial extrusion bioprinting platform is reported. This platform is capable of depositing multiple coded bioinks in a continuous manner with fast and smooth switching among different reservoirs for rapid fabrication of complex constructs, through digitally controlled extrusion of bioinks from a single printhead consisting of bundled capillaries synergized with programmed movement of the motorized stage.

Keywords: bioinks; bioprinting; hydrogels; multimaterial; tissue engineering.

MeSH terms

Bioprinting*
Tissue Engineering
Tissue Scaffolds

Abstract

MeSH terms

Grants and funding