High Frequency of OXA-253-Producing Acinetobacter baumannii in Different Hospitals in Recife, Brazil

Antimicrob Agents Chemother. 2016 Dec 27;61(1):e01309-16. doi: 10.1128/AAC.01309-16. Print 2017 Jan.

Abstract

Here, we report the isolation of 31 Acinetobacter baumannii strains producing OXA-253 in a single large Brazilian city. These strains belonged to five different sequence types (STs), including 4 STs not previously associated with blaOXA-253 In all strains, the blaOXA-253 gene was located in a plasmid within a genetic environment similar to what was found previously in Brazil and Italy. The reported data emphasize the successful transmission of the blaOXA-253 gene through a large area and the tendency for this resistance determinant to remain in the A. baumannii population.

Keywords: Acinetobacter; MLST; antibiotic resistance; genome analysis; oxacillinase.

MeSH terms

  • Acinetobacter baumannii / drug effects*
  • Acinetobacter baumannii / enzymology
  • Acinetobacter baumannii / genetics
  • Anti-Bacterial Agents / pharmacology*
  • Brazil
  • Hospitals
  • Italy
  • Microbial Sensitivity Tests
  • Plasmids / genetics
  • beta-Lactamases / genetics
  • beta-Lactamases / metabolism*

Substances

  • Anti-Bacterial Agents
  • beta-Lactamases
  • oxacillinase