Prevalence of Colistin Resistance Gene mcr-1 and Absence of mcr-2 in Escherichia coli Isolated from Healthy Food-Producing Animals in Japan

Antimicrob Agents Chemother. 2016 Dec 27;61(1):e02057-16. doi: 10.1128/AAC.02057-16. Print 2017 Jan.

Abstract

We screened mcr-1 and mcr-2 genes in 9,306 Escherichia coli strains isolated from healthy animals in the Japanese Veterinary Antimicrobial Resistance Monitoring (JVARM) system. mcr-1 was detected in 39 strains (5, 20, and 14 strains isolated from cattle, swine, and broilers, respectively), whereas mcr-2 was not detected. mcr-2 was also not detected with the investigation sequence homology search against our curated GenEpid-J database.

Keywords: GenEpid-J; Japanese Veterinary Antimicrobial Resistance Monitoring system; colistin resistance; food-producing animals; mcr-1; mcr-2.

MeSH terms

  • Animal Husbandry
  • Animals
  • Anti-Bacterial Agents / pharmacology
  • Cattle
  • Chickens
  • Colistin / pharmacology
  • Drug Resistance, Bacterial / genetics*
  • Escherichia coli / drug effects
  • Escherichia coli / genetics
  • Escherichia coli / growth & development
  • Escherichia coli / isolation & purification
  • Escherichia coli Infections / epidemiology
  • Escherichia coli Infections / microbiology
  • Escherichia coli Infections / veterinary*
  • Escherichia coli Proteins / genetics*
  • Escherichia coli Proteins / metabolism
  • Gene Expression
  • Japan / epidemiology
  • Meat / microbiology*
  • Poultry Diseases / epidemiology*
  • Poultry Diseases / microbiology
  • Prevalence
  • Protein Isoforms / genetics
  • Protein Isoforms / metabolism
  • Swine
  • Swine Diseases / epidemiology*
  • Swine Diseases / microbiology

Substances

  • Anti-Bacterial Agents
  • Escherichia coli Proteins
  • MCR-1 protein, E coli
  • Protein Isoforms
  • Colistin