Background: Attitudes about the risks associated with substance use have historically been closely related to their use. Because college is a period of life when many young adults are exposed to or engage in substance use, examining college students' attitudes about the risks associated with using substances and their perception of the availability of substances provides needed prevention information. Method: The 2014 National Survey on Drug Use and Health (NSDUH) estimates of perceptions of great risk of harm from substance use and perceptions of availability of substances among young adults aged 18 to 22 were analyzed by full-time college student status. Additionally, the 2014 estimates for full-time college students were compared with estimates from 2002 to 2013 to examine changes in these measures over time. Results: Findings in this report indicate that college students were less likely than young adults who were not full-time college students to perceive great risk of harm from monthly cocaine use, trying heroin, or trying LSD. The long-term trend analysis also suggests that college student perceptions of risk and availability have been relatively stable since the late 2000s, with the exception of LSD and marijuana. Conclusion: Monitoring college student attitudes regarding the risk and availability of substances, as well as changes over time, may help address substance use on college campuses, including efforts to raise awareness about the consequences of substance use and to improve prevention efforts.