Abstract
A new cycloartane-type triterpenoid, named 22-hydroxy-cyclolaudenol (1), together with two known cycloartane-type triterpenoids were isolated from the roots of Dianella ensifolia. Their structures were determined based on spectroscopic methods, including UV, IR, HR-ESI-MS, NMR and X-ray diffraction. Compound 1 displayed cytotoxic effects against cancer cell lines B16-F10, A549 and MDA-MB-231.
Keywords:
Cycloartane-type triterpenoids; Dianella ensifolia; cytotoxicity.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology*
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Cell Line, Tumor
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Drug Screening Assays, Antitumor / methods
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Hep G2 Cells / drug effects
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Heterocyclic Compounds, 4 or More Rings / chemistry
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Humans
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Inhibitory Concentration 50
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MCF-7 Cells / drug effects
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Magnetic Resonance Spectroscopy
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Magnoliopsida / chemistry*
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Molecular Structure
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Plant Roots / chemistry
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Spectrometry, Mass, Electrospray Ionization
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Spectrophotometry, Ultraviolet
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Steroids / chemistry
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Steroids / isolation & purification
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Steroids / pharmacology
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Triterpenes / chemistry*
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Triterpenes / isolation & purification
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X-Ray Diffraction
Substances
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22-hydroxy-cyclolaudenol
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Antineoplastic Agents, Phytogenic
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Heterocyclic Compounds, 4 or More Rings
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Steroids
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Triterpenes
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cycloneolitsol
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pholidonone
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cycloartane