Abstract
Cryptochromes are blue-light receptors that regulate development and the circadian clock in plants and animals. We found that Arabidopsis cryptochrome 2 (CRY2) undergoes blue light-dependent homodimerization to become physiologically active. We identified BIC1 (blue-light inhibitor of cryptochromes 1) as an inhibitor of plant cryptochromes that binds to CRY2 to suppress the blue light-dependent dimerization, photobody formation, phosphorylation, degradation, and physiological activities of CRY2. We hypothesize that regulated dimerization governs homeostasis of the active cryptochromes in plants and other evolutionary lineages.
Copyright © 2016, American Association for the Advancement of Science.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Arabidopsis / genetics
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Arabidopsis / metabolism*
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Arabidopsis / radiation effects
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Arabidopsis Proteins / chemistry*
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Arabidopsis Proteins / genetics
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Arabidopsis Proteins / radiation effects
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Cryptochromes / chemistry*
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Cryptochromes / radiation effects*
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Gene Expression Regulation, Plant / radiation effects
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Homeostasis
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Light
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Phosphorylation
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Photochemical Processes
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Plants, Genetically Modified / genetics
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Plants, Genetically Modified / metabolism
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Plants, Genetically Modified / radiation effects
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Protein Binding
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Protein Multimerization / radiation effects
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Proteolysis / radiation effects
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Transcriptome / radiation effects
Substances
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Arabidopsis Proteins
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CRY2 protein, Arabidopsis
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Cryptochromes