Dynamic covalent single chain nanoparticles based on hetero Diels-Alder chemistry

Nils Wedler-Jasinski; Thorsten Lueckerath; Hatice Mutlu; Anja S Goldmann; Andreas Walther; Martina H Stenzel; Christopher Barner-Kowollik

doi:10.1039/c6cc07427h

Dynamic covalent single chain nanoparticles based on hetero Diels-Alder chemistry

Chem Commun (Camb). 2016 Dec 20;53(1):157-160. doi: 10.1039/c6cc07427h.

Authors

Nils Wedler-Jasinski¹, Thorsten Lueckerath¹, Hatice Mutlu¹, Anja S Goldmann², Andreas Walther³, Martina H Stenzel⁴, Christopher Barner-Kowollik²

Affiliations

¹ Preparative Macromolecular Chemistry, Institut für Technische Chemie und Polymerchemie, Karlsruhe Institute of Technology (KIT), Engesserstr. 18, 76128 Karlsruhe, Germany. christopher.barner-kowollik@kit.edu and Institut für Biologische Grenzflächen (IBG), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany.
² Preparative Macromolecular Chemistry, Institut für Technische Chemie und Polymerchemie, Karlsruhe Institute of Technology (KIT), Engesserstr. 18, 76128 Karlsruhe, Germany. christopher.barner-kowollik@kit.edu and Institut für Biologische Grenzflächen (IBG), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany and School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology (QUT), 2 George Street, QLD 4000, Brisbane, Australia. christopher.barnerkowollik@qut.edu.au.
³ Institute for Macromolecular Chemistry, Albert-Ludwigs-University of Freiburg, Stefan-Meier-Str. 31, 79104 Freiburg, Germany. andreas.walther@makro.uni-freiburg.de.
⁴ Centre for Advanced Macromolecular Design (CAMD), The University of New South Wales, Sydney, NSW 2052, Australia. m.stenzel@unsw.edu.au.

PMID: 27844066
DOI: 10.1039/c6cc07427h

Abstract

We introduce the fully reversible folding of single chain nanoparticles (SCNPs) based on covalent hetero Diels-Alder (HDA) chemistry. A cyclopentadiene (Cp)-protected cyanodithioester (CDTE) monomer is designed and copolymerized with methyl methacrylate (MMA) via RAFT polymerization. The polymer chains are folded and subsequently unfolded by exploiting the reversible nature of the HDA reaction.