Antibiotic Release from Calcium Phosphate Materials in Oral and Maxillofacial Surgery. Molecular, Cellular and Pharmaceutical Aspects

Abstract

Calcium phosphate materials (CPM) are widely used in dentistry and maxillofacial surgery. The presence of microbial biofilms and external infections is responsible for the failure of many procedures of dental implants and bone grafts. In an attempt to reduce the percentage of these infectious processes antibiotics have been associated with CPM improving certain conditions. For instance, antibiotics administered orally or intravenously have less effect and the blood flow in relation to this is poor near implants and grafts. Tissue engineering (TE) has employed CPM as a local drug delivery vehicle to be more effective and efficient in bone infections. This review is presented to describe current antibiotics used and the physical and chemical properties of scaffolds.

Keywords: Antibiotics; bone infections; calcium phosphate materials; dentistry; drug delivery; maxillofacial surgery; tissue engineering.