Gut microbiota modulate host immune cells in cancer development and growth

Free Radic Biol Med. 2017 Apr:105:28-34. doi: 10.1016/j.freeradbiomed.2016.11.013. Epub 2016 Nov 10.

Abstract

Emerging evidence shows that microbe interactions with the host immune system impact diverse aspects of cancer development and treatment. As a result, exciting new opportunities exist for engineering diets and microbe cocktails to lower cancer risks with fewer adverse clinical effects than traditional strategies. Microbe-based therapies may ultimately be used to reinforce host immune balance and extinguish cancer for generations to come.

Keywords: Bacteria; Health; Homeostasis; Hygiene; Lymphocyte; Neutrophil; Thymus.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • CD4-Positive T-Lymphocytes / immunology
  • CD4-Positive T-Lymphocytes / microbiology*
  • Carcinogenesis / immunology
  • Gastrointestinal Microbiome / immunology*
  • Homeostasis
  • Humans
  • Immunity, Innate
  • Neoplasms / immunology
  • Neoplasms / microbiology*
  • Neoplasms / pathology
  • Protective Factors