Abstract
Papillomavirus life cycle is tightly coupled to epithelial cell differentiation, which has hindered the investigation of many aspects of papillomavirus biology, including virion assembly. The development of in vitro production methods of papillomavirus pseudoviruses, and the production of "native" virus in raft cultures have facilitated the study of some aspects of the assembly process. In this paper we review the current knowledge of papillomavirus assembly, directions for future research, and the implications of these studies on new therapeutic interventions.
Keywords:
Papillomavirus; Pseudovirus; Virion assembly.
Published by Elsevier B.V.
Publication types
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Review
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Research Support, N.I.H., Intramural
MeSH terms
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Capsid Proteins / chemistry
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Capsid Proteins / genetics
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Capsid Proteins / metabolism
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Cell Differentiation
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Genome, Viral*
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Host-Pathogen Interactions
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Humans
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Keratinocytes / metabolism
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Keratinocytes / virology
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Papillomaviridae / genetics*
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Papillomaviridae / growth & development
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Papillomaviridae / pathogenicity
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Papillomaviridae / ultrastructure
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Papillomavirus Infections / genetics
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Papillomavirus Infections / metabolism
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Papillomavirus Infections / pathology
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Papillomavirus Infections / virology
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Virion / genetics*
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Virion / growth & development
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Virion / pathogenicity
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Virion / ultrastructure
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Virus Assembly*
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Virus Replication*