Intra-myocardial growth hormone administration ameliorates arrhythmogenesis during ischemia-reperfusion in rats

Marianthi Kontonika; Eleonora Barka; Maria Roumpi; Agapi D Vilaeti; Giannis G Baltogiannis; Antonios P Vlahos; Simeon Agathopoulos; Theofilos M Kolettis

doi:10.1016/j.jelectrocard.2016.10.004

Intra-myocardial growth hormone administration ameliorates arrhythmogenesis during ischemia-reperfusion in rats

J Electrocardiol. 2017 Mar-Apr;50(2):207-210. doi: 10.1016/j.jelectrocard.2016.10.004. Epub 2016 Oct 18.

Authors

Marianthi Kontonika¹, Eleonora Barka², Maria Roumpi², Agapi D Vilaeti³, Giannis G Baltogiannis⁴, Antonios P Vlahos⁵, Simeon Agathopoulos⁴, Theofilos M Kolettis⁶

Affiliations

¹ Department of Cardiology, Medical School, University of Ioannina, Greece; Cardiovascular Research Institute, Ioannina, Greece.
² Cardiovascular Research Institute, Ioannina, Greece; Ceramics and Composites Laboratory, Department of Materials Science and Engineering, University of Ioannina, Greece.
³ Department of Cardiology, Medical School, University of Ioannina, Greece.
⁴ Cardiovascular Research Institute, Ioannina, Greece.
⁵ Pediatric Cardiology, Sector of Child Health, Medical School, University of Ioannina, Greece.
⁶ Department of Cardiology, Medical School, University of Ioannina, Greece; Cardiovascular Research Institute, Ioannina, Greece. Electronic address: theofilos.m.kolettis@gmail.com.

PMID: 27839834
DOI: 10.1016/j.jelectrocard.2016.10.004

Abstract

Growth hormone, currently under evaluation for the prevention of left ventricular remodeling post-myocardial infarction, displays antiarrhythmic properties in the acute setting. However, it is uncertain whether these actions are retained after ischemia/reperfusion. Using implanted telemetry transmitters, we examined the effects of prolonged, intra-myocardial growth hormone administration in conscious rats. During a 24-h observation period, ventricular tachyarrhythmias and sympathetic activation were attenuated in treated rats, whereas infarct-size was unchanged. These findings call for further study on the antiarrhythmic effects of growth hormone and on the underlying mechanisms.

Keywords: Growth hormone; Ischemia; Reperfusion; Scaffold; Sympathetic activation; Ventricular arrhythmias.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Arrhythmia Agents / administration & dosage
Growth Hormone / administration & dosage*
Myocardial Reperfusion Injury / complications*
Myocardial Reperfusion Injury / diagnosis
Myocardial Reperfusion Injury / drug therapy*
Rats
Rats, Wistar
Tachycardia, Ventricular / complications*
Tachycardia, Ventricular / diagnosis
Tachycardia, Ventricular / prevention & control*
Treatment Outcome

Substances

Anti-Arrhythmia Agents
Growth Hormone